Pamplemousse et oraux

MuscleMachine

a.k.a. MM
MEMBRE APPROUVÉ
VÉTÉRAN
Je tente de chercher si vraiment le jus de pamplemousse augmenterait lefficacité des stéroides oraux et dautres formes de médicaments telles que la T3 par exemple. Est-ce un mythe ou la réalité ? Si vous avez des articles ou des expériences la-dessus, vous pouvez les joindres ici :smil3e557e75e6dd4: :smil3e557e760643b:
Voici ce que jai trouvé jusquà présent :

[Does grapefruit juice increase the bioavailability of orally administered sex steroids?][Article in Czech]
Fingerova H, Oborna I, Petrova P, Budikova M, Jezdinsky J.
Klinika porodnictvi a gynekologie LF UP v Olomouci.

OBJECTIVE: To verify if and to which extent the interaction with grapefruit juice can increase bioavailability of orally administered sexual steroids. DESIGN: Pilot pharmacokinetics study. SETTING: Department of Obstetrics and Gynecology and Institute of Pharmacology, Medical Faculty, Palacky University, Olomouc; Department of Nuclear Medicine, University Hospital, Olomouc. METHODS: 2 mg of estradiol valerate and 100 mg of micronized progesterone were given to eight healthy postmenopausal volunteers. Blood samples were collected at time 0, 2, 3, 5 and 24 hours after tablets application. The same trial was repeated a week later but tablets were swallowed with 200 ml of grapefruit juice. Serum levels of estradiol and progesterone were measured by RIA. Results were statistically evaluated using the Wilcoxon's nonparametric paired test. RESULTS: Though grapefruit juice on average slightly increased serum levels of estradiol (E2) and progesterone, this increase reached statistical significance only for the E2 level 24 hours after application of tablets. The mean area under curve (AUC) of estradiol rose significantly to 117%. The even greater increase in the mean AUC of progesterone (to 125%) was not statistically significant because of marked individual variability of response. CONCLUSIONS: Our results suggest that grapefruit juice may increase bioavailability of orally administered estradiol and progesterone. The response varies markedly between individuals. This observation may be of some importance also for users of OC and HRT.

PMID: 12749182 [PubMed - indexed for MEDLINE]
 

MuscleMachine

a.k.a. MM
MEMBRE APPROUVÉ
VÉTÉRAN
Interaction du jus de pamplemousse avec la felodipine (médicament pour traiter lhypertension)



Effet du jus de pamplemousse sur la concentration plasmatique de felodipine. Les concentrations plasmatique de felodipine ont été mesurées après ladministration orale de 10 mg de felodipine avec de leau (
), après un premier 8 once de jus de pamplemousse (
), et après 5 jours consécutifs dadministration de jus de pamplemousse (
).

http://www.jci.org/cgi/content/full/99/10/2545
 

ziva3000

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VÉTÉRAN
moi tout ce que j'ai lu sur ce fruit est qu'il fait perdre du gras ( cf: muscle et fitness )
 

davidgiaco

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moi le seul truc que je trouve a ces fruits c'est leur bon gout !!!!:happy052: :D :00000005:
 
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